• 

  朱麟勇

         特聘教授，博士生导师。1995在北京师范大学获得本科学位，2000年在中科院感光化学研究所获得博士学位，2003年至2007年，先后在美国华盛顿州立大学和加州大学圣地亚哥分校从事博士后研究工作。2008年回国，被华东理工大学聘为特聘教授，2012年被聘为上海市“东方学者”特聘教授，2014年获得国家杰出青年科学基金资助，2015年获上海市“东方学者”跟踪。2020年被js345线路检测聘为特聘教授。

  长期聚焦于生物医用材料，特别是“光化学方法构建生物医用材料”方向。1）提出人工合成生色团的“拟荧光蛋白”的构建，创制高特异、高亮度、从蓝光至近红外光发射任意调控的系列荧光探针，成功应用于蛋白与 mRNA 的荧光成像、定量以及相互作用等实时动态研究；2）提出“光偶联反应”创新交联机制，实施高机械强度与强组织粘附的水凝胶生物材料的超快构建，实现大动物心脏穿透伤导致大流量出血与动脉损伤的瞬时封闭，并由此推动医用光敏生物胶领先技术的临床转化。这些成果发展光化学方法解决生命与医学中的重要问题，充分体现“光”的可视与可控的独特优势。先后在 Nat. Biotechnol.、Nat. Chem. Biol.、Sci. Adv.、Adv. Mater.、J. Am. Chem. Soc.、Angew. Chem.、Nat. Commun. 等学术期刊上发表论文80余篇，申/获专利30余项。主持或负责国家重点研发计划、军委科技委、国家自然科学基金、上海市人才计划等十余项项目。

1.  水凝胶生物医用材料

2.  3D打印

3.  化学与生物荧光传感

1.    Kaiyi Huang, Xianjun Chen, Chunyan Li, Qianqian Song, Huiwen Li, Linyong Zhu*, Yi Yang*, Aiming Ren*, Structure-based investigation of fluorogenic Pepper aptamer. Nat. Chem. Biol., 2021, accepted.

2.    Wenjie Zhang, Bingkun Bao, Fei Jiang, Yiqing Zhang, Renjie Zhou, Yuezhi Lu, Sihan Lin, Qiuning Lin*, Xinquan Jiang*, Linyong Zhu*, Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S‐Nitrosylation Coupling Reaction. Adv. Mater., 2021, DOI: 10.1002/adma.202105667.

3.   Yujie Hua, Huitang Xia, Litao Jia, Jinzhong Zhao, Dandan Zhao, Xiaoyu Yan, Yiqing Zhang, Shengjian Tang, Guangdong Zhou*, Linyong Zhu, Qiuning Lin*. Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy. Sci. Adv., 2021, 7, eabg0628.

4.   Jian Zhang, Yongjun Zheng, Jimmy Lee, Jieyu Hua, Shilong Li, Ananth Panchamukhi, Jiping Yue, Xuewen Gou, Zhaofan Xia, Linyong Zhu*, Xiaoyang Wu*. A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing. Nat. Commun., 2021, 12, 1670.

5.    Xianjun Chen, Dasheng Zhang, Ni Su, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Lixin Zhang, Yuzheng Zhao, Linyong Zhu*, Joseph Loscalzo, Yi Yang*, Visualizing RNA Dynamics in live cells with bright and stable fluorescent RNAs. Nat. Biotechnol., 2019, 37, 1287-1293.

6.    Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Chengyao Ni, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Yiwei Zou, Dongsheng Yu, Jinwei Zhang, David E. Arnot, Boon Chin Heng, Xiaohui Zou, Linyong Zhu*, Shufang Zhang *, & Hongwei Ouyang*, A strongly adhesive haemostatic hydrogel for the repair of arterial and heart bleeds. Nat. Commun., 2019, 10, 2060.

7.   Qiuning Lin, Lipeng Yang, Zhiqiang Wang, Yujie Hua, Dasheng Zhang, Bingkun Bao, Chunyan Bao, Xueqing Gong, Linyong Zhu*, Coumarin Photocages Modified with an Electron-Rich Styryl Moiety at the 3-Position: Long Wavelength Excitation, Rapid Photolysis and Photobleaching. Angew Chem Int. Ed., 2018, 57, 3722.

8.   Sujun Chen, Yichun Wang, Ting Nie, Chunyan Bao*, Chenxi Wang, Tianyi Xu, Qiuning Lin, Da-Hui Qu, Xueqing Gong, Yi Yang, Linyong Zhu* Sujun Chen, Sujun ChenKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science & Technology, 130 Meilong Road, Shanghai, 200237, ChinaAn artificial molecular shuttle operates in lipid bilayers for ion transport. J. Am. Chem. Soc., 2018, 140, 17992.

9.   Zunzheng Ming, Jinyan Fan, Chunyan Bao*, Yuan Xue, Qiuning Lin, Linyong Zhu*, Photogenerated Aldehydes for Protein Patterns on Hydrogels and Guidance of Cell Behavior. Adv. Funct. Mater., 2018, 1706918.

10.  Zunzheng Ming, Xing Ruan, Chunyan Bao*, Qiuning Lin, Yi Yang, Linyong Zhu*, Micropatterned Protein for Cell Adhesion through Phototriggered Charge Change in a Polyvinylpyrrolidone Hydrogel. Adv. Funct. Mater., 2017, 27, 1606258.

11.  Yunlong Yang, Jieyuan Zhang, Zhenzhen Liu, Qiuning Lin*, Xiaolin Liu, Chunyan Bao, Yang Wang*, Linyong Zhu*, Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction. Adv. Mater., 2016, 28, 2724-2730.

12.  Zhenzhen Liu, Tao Liu, Qiuning Lin, Chunyan Bao, Linyong Zhu*, Sequential Control over Thiol Click Chemistry by a Reversibly Photoactivated Thiol Mechanism of Spirothiopyran. Angew Chem Int. Ed., 2015, 54, 174-178.

13.  Chunyan Bao, Linyong Zhu*, Qiuning Lin, He Tian, Building Biomedical Materials using Photochemical Bond Cleavage. Adv. Mater., 2015, 27, 1647-1662.

14.  Linzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Linyong Zhu*, Fuyou Li*, Near-Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk-Shell Upconversion Nanocages. Adv. Funct. Mater., 2014, 24, 363-371.

15. Zhenzhen Liu, Qiuning Lin, Yun Sun, Tao Liu, Chunyan Bao, Fuyou Li, Linyong Zhu*, Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction. Adv. Mater., 2014, 26, 3912-3917.

16.  Qiuning Lin, Chunyan Bao, Yunlong Yang, Qiannan Liang, Dasheng Zhang, Shuiyu Cheng, Linyong Zhu*, Highly Discriminating Photorelease of Anticancer Drugs Based on Tumor- Hypoxia Activatable Phototriggers Conjugated Chitosan Nanoparticles. Adv. Mater., 2013, 24, 1981-1986.

17.   Qiuning Lin, Chunyan Bao, Shuiyu Cheng, Yunlong Yang, Wei Ji, Linyong Zhu*, Target-Activated Coumarin Phototriggers Specifically Switch on Fluorescence and Photocleavage upon Bonding to Thiol-Bearing Protein. J. Am. Chem. Soc., 2012, 134, 5052-5055.

18.  Qiuning Lin, Qi Huang, Chunyan Li, Chunyan Bao*, Zhenzhen Liu, Fuyou Li, Linyong Zhu*, Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process. J. Am. Chem. Soc., 2010, 132, 10645-10647.

19.   Linyong Zhu, Wuwei Wu, Mingqiang Zhu, Jason J. Han, James K. Hurst*, Alexander D. Q. Li*, Reversibly Photoswitchable Dual-Color Fluorescence Nanoparticles as a New Tool for Cell Imaging. J. Am. Chem. Soc., 2007, 129, 3524-3526.

20.    Linyong Zhu, Rafail F. Khairutdinov, James K. Hurst*, Photoregulated Transmembrane Charge Separation by Linked Spiropyran- Anthraquinone Molecules. J. Am. Chem. Soc., 2006, 128, 825-835.

21.  Linyong Zhu, Mingqiang Zhu, James K. Hurst*, Alexander D. Q. Li*, Light-Controlled Molecular Switches Modulate Nanocrystal Fluorescence. J. Am. Chem. Soc., 2005, 127, 8968-8970.